| ...And Stay Down (10) | Kill 25 crawling enemies with Stomp (single player only) |
| Bouncing Betty (10) | Kill a Cyst by catching its Mine and throwing it back |
| Brute Juke (10) | Kill a Brute without taking damage |
| C-Section (10) | Knock down an enemy with Contact Beam Alt-Fire then kill it with Primary Fire before it stands up |
| Clean Cut (10) | Sever all three tentacles of a Lurker with one Line Gun Primary Fire shot (single player only) |
| Clever Girls (10) | Survive your first encounter with Stalkers |
| Collect Peng (20) | Find the Peng treasure |
| Cross your Heart, Hope to Die (30) | Survive the Eye Poke Machine |
| Derailed (20) | Survive the Train Sequence |
| Elevator Action (15) | Knock off every Tripod during the Elevator Sequence |
| Epic Dismemberment (50) | Dismember 2,500 Necromorph Limbs (single player only) |
| First Aid (10) | Use Quick Heal ten times (single player only) |
| Frozen in Time (10) | Kill 50 Necromorphs while they are in Stasis (single player only) |
| Fully Loaded (50) | Simultaneously have four completely upgraded weapons |
| Fully Outfitted (30) | Upgrade your RIG and Stasis completely |
| Going for Distance (20) | Impale an enemy and make him fly through the air for 17 meters - it must stick to the surface |
| Hard to the Core (50) | Complete the game on Hard Core setting |
| Hornet's Nest (30) | Destroy the Tripod Nest |
| It's a Trap! (20) | Kill 20 enemies with Detonator Mines in a deployed state |
| Knock Knock (25) | Complete the Drill Ride |
| Lawnmower Man (10) | Kill 4 enemies with the same Ripper blade |
| Lightspeed de Milo (10) | Dismember the Lightspeed Boy Statue |
| Looking good (10) | Purchase the Advanced Suit |
| Made Us Whole (10) | Complete the game on any difficulty setting |
| Mission Impossible (50) | Complete the game on Zealot setting |
| My Boom Stick (20) | Kill 6 enemies at once with Line Gun's Alt-Fire (single player only) |
| Necro Flambé (10) | Kill 50 enemies using the Flamethrower |
| One Small Step (10) | Get through the first Zero-G area |
| Operation! (15) | Snare the Shard with the Ishimura |
| Patient on the Loose (15) | Get your first Suit |
| Peek a Boo! (20) | Kill a Stalker with the Seeker Rifle while in Zoom Mode |
| Picking favorites (30) | Upgrade 1 Weapon completely |
| Powered Up (15) | Complete the Solar Array Puzzle |
| Romper Stomper (25) | Stomp 10 Containers |
| Shock Therapy (10) | Impale an enemy with the Javelin Gun and use its Alt-Fire to shock 3 others (single player only) |
| Shoot the Limbs! (10) | Dismember 25 Necromorph Limbs (single player only) |
| Shut Down (10) | Defeat the AI |
| Skewered in Space (15) | Impale an enemy into a Decompression Window to cause it to blow out |
| Taste of your own Medicine (20) | TK Impale a live Slasher to a surface using a Slasher's arm - it must stick to the surface |
| The Electrician (10) | Collect 10 Semiconductors |
| The Engineer (10) | Collect 10 Schematics |
| The Final Sacrifice (50) | Destroy the Marker |
| The Fugitive (50) | Escape the Facility |
| The Graduate (20) | Win the fight at the School |
| The Librarian (10) | Collect 100 logs |
| The Nanny (10) | Kill 30 Crawlers without detonating them |
| The Sampler Platter (20) | Kill a Necromorph with every Weapon in the game (single player only). |
| Think Fast (15) | Kill 30 Necromorphs with Kinesis objects |
| Torment Me No More (20) | Kill the Tormenter |
| Vacuum Cleaner (30) | Decompress 20 Necromorphs without getting sucked out yourself |
